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Hiroshi Shimizu Selected Research

Epidermolysis Bullosa

1/2021Intravenous Injection of Muse Cells as a Potential Therapeutic Approach for Epidermolysis Bullosa.
12/2017Loss of interaction between plectin and type XVII collagen results in epidermolysis bullosa simplex.
4/2017Altered balance of epidermis-related chemokines in epidermolysis bullosa.
10/2016Silicone medical adhesive removers for hyperkeratosis in epidermolysis bullosa.
10/2010Plectin deficiency leads to both muscular dystrophy and pyloric atresia in epidermolysis bullosa simplex.
8/2010Bone marrow transplantation restores epidermal basement membrane protein expression and rescues epidermolysis bullosa model mice.
3/2010Plectin expression patterns determine two distinct subtypes of epidermolysis bullosa simplex.
12/2007Human bullous pemphigoid antigen 2 transgenic skin elicits specific IgG in wild-type mice.
1/2006Colocalization of multiple laminin isoforms predominantly beneath hemidesmosomes in the upper lamina densa of the epidermal basement membrane.

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Hiroshi Shimizu Research Topics

Disease

55Bullous Pemphigoid (Pemphigoid)
12/2021 - 08/2003
22Neoplasms (Cancer)
10/2021 - 02/2004
15Blister (Bulla)
12/2021 - 04/2006
14Ichthyosis (Xeroderma)
01/2019 - 11/2003
14Epidermolysis Bullosa Dystrophica (Dystrophic Epidermolysis Bullosa)
01/2019 - 02/2002
11Melanoma (Melanoma, Malignant)
11/2020 - 02/2004
11Pemphigus (Pemphigus Vulgaris)
03/2020 - 01/2002
11Atopic Dermatitis (Atopic Eczema)
03/2017 - 02/2005
10Autoimmune Diseases (Autoimmune Disease)
01/2019 - 03/2007
10Lamellar Ichthyosis (Harlequin Ichthyosis)
07/2010 - 07/2005
9Epidermolysis Bullosa
01/2021 - 01/2006
8Inflammation (Inflammations)
01/2019 - 04/2004
8Epidermolysis Bullosa Simplex (Epidermolysis Bullosa Herpetiformis Dowling Meara)
12/2017 - 06/2002
6Psoriasis (Pustulosis Palmaris et Plantaris)
04/2016 - 09/2002
6Ichthyosis Vulgaris (Dominant Ichthyosis Vulgaris)
07/2014 - 02/2007
6Epidermolytic Hyperkeratosis (Bullous Congenital Ichthyosiform Erythroderma)
05/2011 - 02/2002
5Pruritus (Itching)
03/2021 - 02/2005
5Stevens-Johnson Syndrome (Lyell's Syndrome)
11/2019 - 05/2003
5Starvation
01/2019 - 05/2007
5Erythema
11/2016 - 01/2003
5Skin Diseases (Skin Disease)
05/2012 - 06/2002
4Sarcoma (Soft Tissue Sarcoma)
10/2021 - 11/2006
4Epidermolysis Bullosa Acquisita (Acquired Epidermolysis Bullosa)
12/2019 - 06/2003
4Hypersensitivity (Allergy)
06/2019 - 09/2006
4Mycosis Fungoides
03/2019 - 05/2006
4Asthma (Bronchial Asthma)
12/2018 - 11/2006
4Contact Dermatitis (Eczema, Contact)
03/2017 - 05/2003
4Muscular Dystrophies (Muscular Dystrophy)
04/2011 - 02/2005
4Chanarin-Dorfman Syndrome
10/2010 - 11/2003
4Wounds and Injuries (Trauma)
02/2008 - 01/2005
4Oculocutaneous Albinism (Albinism, Yellow Mutant)
07/2005 - 01/2002
3Type 2 Diabetes Mellitus (MODY)
03/2021 - 01/2009
3Vasculitis (Vasculitides)
04/2019 - 11/2015
3Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
11/2018 - 09/2013
3Linear IgA Bullous Dermatosis
12/2017 - 11/2010
3Neoplasm Metastasis (Metastasis)
08/2017 - 02/2004
3Palmoplantar Keratoderma (Keratosis Palmaris et Plantaris)
09/2015 - 06/2007
3Junctional Epidermolysis Bullosa (Epidermolysis Bullosa Letalis)
09/2009 - 01/2004
2Myotonic Dystrophy (Dystrophia Myotonica)
01/2022 - 04/2016
2Inborn Genetic Diseases (Disease, Hereditary)
01/2021 - 01/2018
2Disease Progression
07/2020 - 04/2015
2Leukocytosis (Pleocytosis)
03/2020 - 01/2020
2Erythema Multiforme
06/2019 - 05/2003

Drug/Important Bio-Agent (IBA)

42AutoantibodiesIBA
12/2021 - 08/2003
28Collagen Type XVIIIBA
10/2020 - 03/2007
26Proteins (Proteins, Gene)FDA Link
01/2022 - 05/2003
21Immunoglobulin G (IgG)IBA
12/2019 - 08/2003
12Pharmaceutical PreparationsIBA
11/2019 - 05/2003
11EpitopesIBA
07/2020 - 12/2009
11Filaggrin ProteinsIBA
12/2018 - 02/2002
11LipidsIBA
11/2011 - 11/2003
10AntigensIBA
10/2020 - 08/2003
10AntibodiesIBA
10/2017 - 06/2003
10Macrophage Migration-Inhibitory FactorsIBA
04/2011 - 03/2002
9Collagen Type VIIIBA
05/2018 - 06/2003
7EnzymesIBA
01/2020 - 05/2003
7AutoantigensIBA
01/2019 - 03/2007
7Keratins (Keratin)IBA
12/2018 - 02/2002
7DNA (Deoxyribonucleic Acid)IBA
04/2011 - 12/2004
6Dipeptidyl-Peptidase IV InhibitorsIBA
03/2021 - 01/2017
6Peptides (Polypeptides)IBA
01/2019 - 02/2002
5Matrix Metalloproteinases (MMPs)IBA
12/2019 - 01/2016
5CollagenIBA
01/2019 - 03/2010
5NitrogenIBA
01/2019 - 12/2004
5PlectinIBA
12/2017 - 02/2005
5Glycine (Aminoacetic Acid)FDA LinkGeneric
07/2014 - 02/2002
4Immunoglobulin E (IgE)IBA
04/2015 - 02/2005
4Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
05/2013 - 04/2004
4Nonsense Codon (Nonsense Mutation)IBA
07/2008 - 12/2003
3CytokinesIBA
01/2020 - 07/2006
3Intravenous Immunoglobulins (IVIG)FDA Link
01/2020 - 04/2009
3Codon (Codons)IBA
01/2019 - 12/2009
3Glucose (Dextrose)FDA LinkGeneric
01/2018 - 12/2016
3ImmunosorbentsIBA
11/2017 - 05/2003
3DapsoneFDA Link
01/2017 - 03/2006
3DesmogleinsIBA
11/2016 - 01/2002
3Keratin-5 (Keratin 5)IBA
09/2013 - 06/2002
3Amino AcidsFDA Link
09/2013 - 05/2007
3pigment epithelium-derived factorIBA
03/2010 - 04/2004
3SteroidsIBA
07/2009 - 04/2002
3Fas Ligand Protein (Fas Ligand)IBA
11/2008 - 05/2003
3Keratin-10IBA
07/2008 - 12/2004
3Indicators and Reagents (Reagents)IBA
10/2007 - 04/2004
3Monophenol Monooxygenase (Tyrosinase)IBA
09/2004 - 01/2002
2Phosphotransferases (Kinase)IBA
10/2021 - 06/2009
2Prednisolone (Predate)FDA LinkGeneric
04/2021 - 04/2009
2VildagliptinIBA
03/2021 - 10/2017
2L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
03/2020 - 08/2017
2CatecholaminesIBA
03/2020 - 07/2004
2Fumarate Hydratase (Fumarase)IBA
01/2020 - 12/2019
2Immunoglobulins (Immunoglobulin)IBA
01/2020 - 03/2010
2Dihydrotachysterol (AT 10)IBA
01/2020 - 12/2004
2Biomarkers (Surrogate Marker)IBA
11/2019 - 01/2018
2Infliximab (Remicade)FDA Link
06/2019 - 02/2018
2Rituximab (Mabthera)FDA Link
02/2019 - 05/2018
2Prion ProteinsIBA
01/2019 - 12/2009

Therapy/Procedure

23Therapeutics
10/2021 - 10/2003
3Hematopoietic Stem Cell Transplantation
03/2016 - 01/2008
3Bone Marrow Transplantation (Transplantation, Bone Marrow)
07/2015 - 07/2004
3Drug Therapy (Chemotherapy)
06/2013 - 01/2008